Yip, like the ladies and gents have said, saddle and bike fit makes the biggest difference. And then I find shorts with less padding (rather than thick padding) are more comfortable. And don't forget the cream.
Here's an interesting article re saddles for "innies" or "outies". The shape at the front of the saddle matters 😉 : https://totalwomenscycling.com/fitness/cobb-saddles-ask-innie-outie
