Well it all depends on you - your strengths
I recently changed from a 9 speed Tiagra to a 10 speed Ultegra groupo
Tiagra had a 39/52 and a 11-25
Ultegra has a 39/53 and a 11-23
I rode for the first time yesterday and was quite a change!
I think i might opt for a 11-25 cassette if I can swap out
On the Blade:
the higher the "high"number - the more speed you will get on the flat
the lower the "low" number the easier you will find the climbs
so a 39/52 vs a 39/53 - the 39/53 will be giver you a higher top end
while a 34/50 vs a 36/50 - the 34/50 will be easier for climbing
on the cassette the reverse applies
the more teeth the easier for climbing
so a 11-23 vs a 11/25 - the 11/25, the 25 tooth blade will make it easier on the climbs
i hope this is correct - im still learning meself