I've done this 'nutter' route twice and am going back again this weekend. The area is simply stunning, but the climbing does make it tough. There is a surprising amount of accomodation at convenient distances along the way and the hosts, being farming people are very special. Planning is definately pretty crucial for bikepacking in remote areas. Most probably better to not do alone in case of a fall, but certainly one of the safest areas to ride a bike in South Africa in terms of traffic and security, in my opinion.