Wyatt Earp Posted July 2, 2014 Share By competitively inhibiting excretion, the drugs stays in the bloodstream longer and is not excreted in the urine, hence masking the drug in a urine test. It is in your system, just not in your urine ( or less will be present in your urine). My previous post was not clear. Apologies Sheriff. Sorry if it looked as if I was referring to you I must say it does speak of masking ,but in actual fact it also increases the plasma concentration of some drugs, thus my logic tells me they should have found Probenecid and something else.I see it is also used to prolong some penicillins and antibiotics.I am not trying to vouch for Darryl, but there is a very high probability he could have ingested this unknowingly. Baroudeur 1 Link to comment Share on other sites More sharing options...
fanievb Posted July 2, 2014 Share No, what you're describing is a diuretic. This is a uricosuric (that is it encourages the kidneys to get rid of uric acid at the expense of other drugs) hence the other drugs are not excreted in the urine at a normally expected rate. It does not make you urinate more. thanks for clearing that up Link to comment Share on other sites More sharing options...
Falco Posted July 2, 2014 Share So what this will all eventually come down to is that he is either guilty of doping (taking it willingly) or stupidity (taking it by accident). Either way, his career is in the toilet. Link to comment Share on other sites More sharing options...
Robodog Posted July 2, 2014 Share I think I had Probenecid recently in hospital to concentrate the effectiveness of the antibiotic in the drain in my broken arm. Carrera Roadie 1 Link to comment Share on other sites More sharing options...
ricochet_rabbit Posted July 2, 2014 Share Probenicid has a half life of 4-17hrs depending on dose. Extensively metabolised in the liver and metabolites and 5-10% unchanged drug excreted in the urine. We usually use this drug to treat Gout. It will improve clearance of uric acid and certain drugs via the kidneys, hence previously used as a masking agent. Poor choice of masking agent these days as so easy to detect. So unlikely anyone with a brain would use it as a masking agent. If found in very low concentrations I would not rule out contamination of other medications in the manufacturing process...just saying Is that even possible...surely pharmaceutical companies have stringent measures in place to prevent this? Link to comment Share on other sites More sharing options...
Gen Posted July 2, 2014 Share Is that even possible...surely pharmaceutical companies have stringent measures in place to prevent this? Jis one would think so.. hell imagine someone dying because of contamination. (Reaction to a drug) Edited July 2, 2014 by Gen Link to comment Share on other sites More sharing options...
Tumbleweed Posted July 2, 2014 Share Depends on its method of clearance and whether it is fat or water soluble. But a safeish estimate is usually around 5x the half life of the drug, which is 2-6 hours dosage dependent. So the potential defence of testing clean after the road race at champs would pretty much be out the window? Link to comment Share on other sites More sharing options...
E1A104 Posted July 2, 2014 Share Yes wont make a difference to his sentence but for myself I would like to know was it tiny traces that are a non issue in reality or was it large doses which would only mean cheating if my understanding is correct. Amount found is noT relevant IMO. Was there and shouldn't be there. Could have been the last few traces leaving his system, only time will tell. I am hoping he is clean but we wait and see. Link to comment Share on other sites More sharing options...
fandacious Posted July 2, 2014 Share Amount found is noT relevant IMO. Was there and shouldn't be there. Could have been the last few traces leaving his system. same with contador and clen Link to comment Share on other sites More sharing options...
Tumbleweed Posted July 2, 2014 Share You get that from your boet's article for tomorrow? As a pariah, you may not be privy to some of the background chatter...well, apart from that with you and your boet Link to comment Share on other sites More sharing options...
_David_ Posted July 2, 2014 Share Sheesh... I see Probenecid has been prohibited in- and out-of-competition since 1987. Misuse in sports:The intake of probenecid causes the body to retain substances, anabolic steroids for example, longer and to excrete them at a slower rate. It can consequently become more difficult to detect the substances in analysis. Probenecid has been prohibited in- and out-of-competition since 1987. Link to comment Share on other sites More sharing options...
TopFuel Posted July 2, 2014 Share So the potential defence of testing clean after the road race at champs would pretty much be out the window? Yeah I would think so. Just on the fact that it doesn't take that long to get of your system anyway. Hence other peoples (correct IMHO) claims that any amount is too much, as it could have just been picked up on the back end of the plasma concentration curve. TALUS 1 Link to comment Share on other sites More sharing options...
Tromp Posted July 2, 2014 Share Mr Clean, Andrew, must be cutting his wrists by now. Link to comment Share on other sites More sharing options...
TALUS Posted July 2, 2014 Share It would be hard to explain accidental ingestion. It is used for very well defined situations. Would highly unlikely be in other drugs or food. Doubt that concentrations will save anybody. Looks grim from the outside. Link to comment Share on other sites More sharing options...
rouxtjie Posted July 2, 2014 Share another interesting question is how come he gooied his toys when there was no selection for CWG knowing that he has this sword over his head.... fanievb 1 Link to comment Share on other sites More sharing options...
awesme Posted July 2, 2014 Share ... Why we / CSA / SAIDS delayed the results... http://www.bicycling.co.za/news-people/why-we-delayed-daryl-impeys-positive-finding/ G Link to comment Share on other sites More sharing options...
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