No Daryl Impey for Tour de France - Positive Test Result

[kosmonooit]

And lets face it, we live in a far from pristine and clockwork society.

 

But how to prove contamination? Mick Rodgers didn't, but the decision in his favor went on the basis of probabilities.

[McD23]

to me its as simple as, if you want to make a successful living as a pro cyclist you have to dope..like many of us stretch our expense claims when we submit our tax returns, or manipulate some figures in order to lessen the tax burden, which is essentially illegal and we can be charged with, many of them dope to gain an advantage, ironically it is not illegal and many of the armchair critics who do engage in illegal transgressions occasionally ( think drunk driving ) are the first to stand in the queue to stone the 'dopers' trying to make a living..is it right ,no..but they must earn money to survive and are victim to an entrenched culture that goings to take a lot more than publically crucifying Lance Armstrong to fix..my two cents.

[TALUS]

 

 

And as I said a few times now, not one single person has been able to explain to me the questions I have around this drug.

Problem is you directed your question at Proffesors and Hub know it all's. I think nobody had the correct credentials you specified.

[TALUS]

I will give you my experience though: I give out an estimated 60 prescriptions for A/B per week. I treat very severe (mostly diabetic) infections. Worldwide figures indicate an average of 60-80% amputations in these situations. Desperate situations in other words. I have not used Probenicid in the last 10years.

 

If anybody (including senior people in pharma or any sportsman) can show that routine A/B are laced routinely or by accident by an unspecified second active substance, they will become very rich. It will amount to huge malpractise suits. It would be catastrophic if a patient had a hypersensitivity reaction or developed blood abnormalities from a drug that was illegally added without labeling it. Both reactions are well described.

 

I am not aware of any commonly used medication that comes with a standardised addition of Probenicid.

 

Allopurinol and Colchicine is the accepted standard of treatment for gout. At times Cortisone and NSAID's are added.

 

It does not increase the concentration of any drug, it merely slows down excretion of some drugs and thus prolonging the plasma half life. This only applies to some drugs. It does not have any or minimal effect on hepatic metabolism.

 

All and all it will have to be "the perfect storm" to be ingested by accident. I hope that "perfect storm" exists. If someone has a plausible explanation I will gladly accept it.

 

PS: it should NOT be used in acute attacks. It can actually worsen acute attacks thus it is used as a chronic medication for gout.

Edited July 6, 2014 by TALUS

[Tumbleweed]

I will give you my experience though: I give out an estimated 60 prescriptions for A/B per week. I treat very severe (mostly diabetic) infections. Worldwide figures indicate an average of 60-80% amputations in these situations. Desperate situations in other words. I have not used Probenicid in the last 10years.

 

If anybody (including senior people in pharma or any sportsman) can show that routine A/B are laced routinely or by accident by an unspecified second active substance, they will become very rich. It will amount to huge malpractise suits. It would be catastrophic if a patient had a hypersensitivity reaction or developed blood abnormalities from a drug that was illegally added without labeling it. Both reactions are well described.

 

I am not aware of any commonly used medication that comes with a standardised addition of Probenicid.

 

Allopurinol and Colchicine is the accepted standard of treatment for gout. At times Cortisone and NSAID's are added.

 

It does not increase the concentration of any drug, it merely slows down excretion of some drugs and thus prolonging the plasma half life. This only applies to some drugs. It does not have any or minimal effect on hepatic metabolism.

 

All and all it will have to be "the perfect storm" ingest by accident. I hope that "perfect storm" exists. If someone has a plausible explanation I will gladly accept it.

 

PS: it should NOT be used in acute attacks. It can actually worsen acute attacks thus it is used as a chronic medication for gout.

 

Tangent question...is Probenicid synthetic? Or does it resemble anything the body produces on its own, like, say, EPO?

[TALUS]

 

 

Tangent question...is Probenicid synthetic? Or does it resemble anything the body produces on its own, like, say, EPO?

I will have to check but 99% sure it is synthetic since it actually "obstructs" normal renal function.

[kosmonooit]

I will have to check but 99% sure it is synthetic since it actually "obstructs" normal renal function.

 

Talus any idea how it could have been inadvertently ingested? and why would he or any other pro athlete use a banned drug as a masking agent? (even if it does have a short 1/2 life)

[Thug]

Eurosport showed a TDF insert whilst broadcasting today's stage that featured Daryl.

[TALUS]

 

 

Talus any idea how it could have been inadvertently ingested? and why would he or any other pro athlete use a banned drug as a masking agent? (even if it does have a short 1/2 life)

Inadvertently: I have been trying to get an angle. Even looked at previous hearings. I did not find one. IT DOES NOT MEAN THERE IS NO EXPLANATION!

 

It was very popular before because it could be used Ad Hoc if testing was suddenly expected at a previously unexpected time (usually out of season training) with longer visible drugs like Testosterone. At the time bloodtests were not routinely done (only urine). Remember that metabolites are usually visible after the drug has been cleared from the blood.

[Joe!]

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[Don Sol]

Wish there was some way of keeping the public in the loop. What is happening. What is the process. Hansie... I mean Daryl has the entire south african cycling fraternity supporting him.

[NotSoBigBen]

http://www.timescolonist.com/sports/failed-doping-test-costs-victoria-swimmer-trip-to-commonwealth-games-1.1197436

[TALUS]

Good. At least a precedent excists. Here is hoping...

[Andymann]

Slight hijack, but regardless of whether he did or didn't, OGE do seem to be struggling a bit without him this year? It looks like he might have been quite a key member in the squad.

[javadude]

... I mean Daryl has the entire south african cycling fraternity supporting him.

 

No he doesn't.

[Shebeen]

http://www.timescolo...games-1.1197436

interesting, that's a good report for those who have hope in him.

 

I know some people are seriously BLACK and WHITE on this one and want to string him from the nearest tree, but I am on the fence here for sure. This is way more grey area than say...that guy who took EPO.