Gen Posted July 2, 2014 Posted July 2, 2014 Depends on its method of clearance and whether it is fat or water soluble. But a safeish estimate is usually around 5x the half life of the drug, which is 2-6 hours dosage dependent. And you know this how?
Pariah Posted July 2, 2014 Posted July 2, 2014 Devil's advocate. I know this quote is going to appear in the media tomorrow, but it's worth posing here now: Why would anyone knowingly take it at the time of champs? Especially when you're defending your title, and are a shoo-in to win, and thus will be tested. You get that from your boet's article for tomorrow?
Baroudeur Posted July 2, 2014 Posted July 2, 2014 Probenicid has a half life of 4-17hrs depending on dose. Extensively metabolised in the liver and metabolites and 5-10% unchanged drug excreted in the urine. We usually use this drug to treat Gout. It will improve clearance of uric acid and certain drugs via the kidneys, hence previously used as a masking agent. Poor choice of masking agent these days as so easy to detect. So unlikely anyone with a brain would use it as a masking agent. If found in very low concentrations I would not rule out contamination of other medications in the manufacturing process...just saying Squier and Andrew Armstrong 2
ryanbritchford Posted July 2, 2014 Posted July 2, 2014 IMO , sorry for you. U are a pro and have a whole team and doctors dedicated to making sure an innocent rider doesn't contaminate himself. Anyone who thinks this began and ended with lance is a moron. Many many more to come. It is the sport of cycling unfortunately, and at a pro level doping is not optional it's mandatory. DARK KNIGHT, intern, mtb_nik and 1 other 4
NielC Posted July 2, 2014 Posted July 2, 2014 According to this newspaper article Daryl Impey has allegedly tested positive for a masking agent used to mask the use of banned substances! http://goo.gl/nYHmKE
NotSoBigBen Posted July 2, 2014 Posted July 2, 2014 According to this newspaper article Daryl Impey has allegedly tested positive for a masking agent used to mask the use of banned substances! http://goo.gl/nYHmKE No way you're kidding me Vangar, fanievb, Baaisikilist and 7 others 10
Wyatt Earp Posted July 2, 2014 Posted July 2, 2014 Someone needs to explain to me how it will act as a masking agent.According to Wiki it does this : Probenecid (Lannett's Probalan) is a uricosuric drug that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia.Probenecid was developed as an alternative to caronamide[1] to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effectsNow the part I highlighted gives me an indication that it's some sort of "booster, trigger or support" for whatever drugs one might be taking, if this is the case then surely they must have found traces of something else ?Please help a brother, I need some clarification here (lekker dom with this medical stuff and I know all the hubbers are professors) BogusOne 1
NotSoBigBen Posted July 2, 2014 Posted July 2, 2014 Someone needs to explain to me how it will act as a masking agent.According to Wiki it does this : Probenecid (Lannett's Probalan) is a uricosuric drug that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia.Probenecid was developed as an alternative to caronamide[1] to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effectsNow the part I highlighted gives me an indication that it's some sort of "booster, trigger or support" for whatever drugs one might be taking, if this is the case then surely they must have found traces of something else ?Please help a brother, I need some clarification here (lekker dom with this medical stuff and I know all the hubbers are professors) Ok let me help you dom okes out here ...... Oh no sorry I'm not in the professorship ..... BogusOne 1
Wez-O Posted July 2, 2014 Posted July 2, 2014 Now I at least know why Impey was faster than me on the Cradle Strava points! BigDL, mtb_nik, Long Wheel Base and 2 others 5
Wyatt Earp Posted July 2, 2014 Posted July 2, 2014 No way you're kidding me I am also shocked :o Baaisikilist 1
eddy Posted July 2, 2014 Posted July 2, 2014 Please help a brother, I need some clarification here (lekker dom with this medical stuff and I know all the hubbers are professors) This is no time to be sarcastic, Sheriff. You know full well that professors are specialists in their chosen fields and often have very little knowledge beyond that. Hubbers on the other hand are mostly specialists in ALL fields and thus much more like the Encyclopedia Brittanica of the online world............ Wyatt Earp, Ozzie NL and Underachiever 3
SwissVan Posted July 2, 2014 Posted July 2, 2014 most of us dont race the TDFNot picking on you, just the concept suggested. I'm so sick of hearing this argument along with ignorance being bliss and "I'm just a funriderracer" does not mean its ok.... Its ok to criticize other because they are professional, but people that do it for fun can do as they please..... oh my hippo where is that picture that says it all
Patchelicious Posted July 2, 2014 Posted July 2, 2014 Can we now flag all of his KOMs in the Cradle? Andrew Steer, Sidekick Racer, Super_mil and 2 others 5
SwissVan Posted July 2, 2014 Posted July 2, 2014 But aren't winners and those who podium always tested? that begs the next question: Who won the TT?
Meezo Posted July 2, 2014 Posted July 2, 2014 would this make Jay Thompson, SA TT CHAMP? Sidekick Racer 1
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